Pharmacokinetics of ethylenediaminemalonatoplatinum(II) (JM-40) during phase I trial
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Pharmacokinetics of piroxantrone in a phase I trial of piroxantrone and granulocyte-colony stimulating factor.
Piroxantrone is an anthrapyrazole derivative with broad antitumor activity in vitro. In previous phase I trials, the dose-limiting toxicity of this agent was myelosuppression. Therefore, a phase I and pharmacokinetic study of a 1-h infusion of piroxantrone in combination with granulocyte-colony stimulating factor was conducted. In this article, we report the results of the pharmacokinetic analy...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1987
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1987.228